Prevalence of Polypoidal Choroidal Vasculopathy Using Non-indocyanine green angiography–based Criteria

Published:September 24, 2021DOI:
      Polypoidal choroidal vasculopathy (PCV) is a form of neovascular age-related macular degeneration characterized by polypoidal lesions and branching vascular networks. Diagnosis has traditionally required the use of invasive indocyanine green angiography; however, recently, a validated noninvasive diagnostic system has been developed that identifies PCV-specific features using OCT and color fundus photography. In this work, we applied this new system to a large population-based ethnic Chinese cohort and successfully identified PCV and related anatomic features. We estimated a population prevalence of 0.31% (95% CI, 0.06%–0.91%) and demonstrated that PCV-related retinal findings were relatively rare in the population.


      Abbreviations and Acronyms:

      AMD (age-related macular degeneration), APOIS (Asia Pacific Ocular Imaging Society), CFP (color fundus photography), ICGA (indocyanine green angiography), PED (pigment epithelial detachment), PCV (polypoidal choroidal vasculopathy), RPE (retinal pigment epithelium)
      To read this article in full you will need to make a payment


      Subscribe to Ophthalmology Retina
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Chen S.J.
        • Cheng C.Y.
        • Peng K.L.
        • et al.
        Prevalence and associated risk factors of age-related macular degeneration in an elderly Chinese population in Taiwan: the Shihpai Eye Study.
        Invest Ophthalmol Vis Sci. 2008; 49: 3126-3133
        • Smith W.
        • Assink J.
        • Klein R.
        • et al.
        Risk factors for age-related macular degeneration: pooled findings from three continents.
        Ophthalmology. 2001; 108: 697-704
        • Kawasaki R.
        • Yasuda M.
        • Song S.J.
        • et al.
        The prevalence of age-related macular degeneration in Asians: a systematic review and meta-analysis.
        Ophthalmology. 2010; 117: 921-927
        • Cheung C.M.G.
        • Lai T.Y.Y.
        • Teo K.
        • et al.
        Polypoidal choroidal vasculopathy: consensus nomenclature and non-indocyanine green angiograph diagnostic criteria from the Asia-Pacific Ocular Imaging Society PCV Workgroup.
        Ophthalmology. 2021; 128: 443-452
        • Majithia S.
        • Tham Y.C.
        • Chee M.L.
        • et al.
        Singapore Chinese Eye Study: key findings from baseline examination and the rationale, methodology of the 6-year follow-up series.
        Br J Ophthalmol. 2020; 104: 610-615
        • Li Y.
        • You Q.S.
        • Wei W.B.
        • et al.
        Polypoidal choroidal vasculopathy in adult Chinese: the Beijing Eye Study.
        Ophthalmology. 2014; 121: 2290-2291