Main Outcome Measures
Abbreviations and Acronyms:CRVO (central retinal vein occlusion), DM (diabetes mellitus), ICD (International Classification of Diseases), RVO (retinal vein occlusion)
- The prevalence of retinal vein occlusion: pooled data from population studies from the United States, Europe, Asia, and Australia.Ophthalmology. 2010; 117: 313-319.e1
- Central retinal vein occlusion: a review.Clin Exp Ophthalmol. 2012; 40: 48-58
- Retinal vein thrombosis: pathogenesis and management.J Thromb Haemost. 2010; 8: 1886-1894
- Retinal vein occlusions Preferred Practice Pattern®.Ophthalmology. 2020; 127: P288-P320
- Laboratory evaluation of hypercoagulable states in patients with central retinal vein occlusion who are less than 56 years of age.Retina (Phila). 2018; 38: 1175-1179
- The Royal College of Ophthalmologists Guidelines on retinal vein occlusions: executive summary.Eye (Lond). 2015; 29: 1633-1638
- Coagulation disorders and the risk of retinal vein occlusion.Thromb Haemost. 2010; 103: 299-305
- Increased prevalence of factor V Leiden in patients with retinal vein occlusion and under 60 years of age.Thromb Haemost. 2005; 94: 101-106
- High prevalence of resistance to APC in young patients with retinal vein occlusion.Graefes Arch Clin Exp Ophthalmol. 2002; 240: 163-168
- No evidence for thrombophilia in patients with retinal venous occlusion: a systematic GRADE-based review.Acta Ophthalmol (Copenh). 2017; 95: 12-19
- Association of retinal vascular occlusion with women filling a prescription for female hormone therapy.JAMA Ophthalmol. 2020; 139: 42-48
- The inherited thrombophilias: genetics, epidemiology, and laboratory evaluation.Best Pract Res Clin Obstet Gynaecol. 2003; 17: 397-411
- Thrombophilic risk factors are uncommon in young patients with retinal vein occlusion.Retina. 2015; 35: 715-719
- The prevalence of activated protein C (APC) resistance and factor V Leiden is significantly higher in patients with retinal vein occlusion without general risk factors.Thromb Haemost. 2008; 99: 925-929
- Bilateral central retinal vein occlusion in a patient with occult colon cancer.Arch Ophthalmol. 2001; 119: 1552-1553
- Central retinal vein occlusion in a patient with breast carcinoma.GMS Ophthalmol Cases. 2019; 9: Doc04
- Simultaneous bilateral central retinal vein occlusion as the first manifestation of chronic myeloid leukemia.Ophthalmol Retina. 2018; 2: 378
- Bilateral central retinal vein occlusion as presenting feature of chronic myeloid leukemia.Middle East Afr J Ophthalmol. 2016; 23: 253-255
- Increased risk of cancer in patients with retinal vein occlusion: a 12-year nationwide cohort study.Br J Ophthalmol. 2020; (In press)
- Laboratory markers in the diagnosis of venous thromboembolism.Circulation. 2004; 109: I4-I8
- Laboratory markers in the diagnosis of venous thromboembolism.Br J Haematol. 2013; 163: 655-665
- Evaluating adult patients with established venous thromboembolism for acquired and inherited risk factors. UpToDate.(Available at:)https://www.uptodate.com/contents/evaluating-adult-patients-with-established-venous-thromboembolism-for-acquired-and-inherited-risk-factorsDate accessed: May 17, 2021
Publication stageIn Press Journal Pre-Proof
Supplemental material available at www.ophthalmologyretina.org.
Disclosure(s): All authors have completed and submitted the ICMJE disclosures form.
The author(s) have no proprietary or commercial interest in any materials discussed in this article.
Supported by the National Institutes of Health , Bethesda, Maryland (grant nos.: 1K23EY025729-01 and 2P30EY001583 ). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Additional funding was provided by Research to Prevent Blindness , Inc., New York, New York; the Karen & Herbert Lotman Fund for Macular Vision Research Foundation, Philadelphia, PA; and the Paul and Evanina Mackall Foundation, Philadelphia, PA . None of the funding organizations had any role in the design or conduction of the study.
HUMAN SUBJECTS: Human subjects were included in this study. This study was deemed exempt from review by the University of Pennsylvania’s Institutional Review Board because of the deidentified nature of the database. All research adhered to the tenets of the Declaration of Helsinki.
No animal subjects were included in this study.
Conception and design: Tauqeer, Bracha, VanderBeek
Analysis and interpretation: Tauqeer, Bracha, VanderBeek
Data collection: McGeehan, VanderBeek
Obtained funding: VanderBeek
Overall responsibility: Tauqeer, Bracha, McGeehan, VanderBeek